Salmon DNA (PN) vs PDRN: What’s the Difference and Which Is Right for You?

“Salmon DNA” treatments have become very popular in Malaysia, but the term covers two different ingredients: polynucleotides (PN) and polydeoxyribonucleotides (PDRN). Both are made from purified salmon DNA, and both aim to support skin repair. However, they differ in size, how they behave in the skin and how they are used. This guide explains the difference, what the evidence shows and which may suit your skin. If you would like a doctor to recommend the right option, contact CLEO Clinic.

What Is Salmon DNA in Skincare?

Salmon DNA treatments use DNA fragments that are extracted and highly purified, usually from salmon or trout. Because the DNA is purified, it is designed to be biocompatible and low in immune reaction. Once in the skin, it is thought to provide building blocks that support cell repair and the environment around skin cells. In short, salmon DNA is used to improve skin quality rather than to add volume.

What Is PN (Polynucleotide)?

PN is made of long DNA chains with a high molecular weight. Because the chains are long, PN forms a gel-like, water-binding structure in the skin. As a result, this structure is thought to act as a temporary scaffold that supports fibroblasts, the cells that make collagen. Rejuran and PLINEST are examples of PN-based skin boosters. To learn more about these, see our Rejuran treatment in KL page and our PLINEST treatment page.

What Is PDRN (Polydeoxyribonucleotide)?

PDRN is made of shorter DNA fragments with a lower molecular weight. According to a 2025 review in Biomolecules, PDRN is broken down into nucleotides that act on receptors on skin cells, which is linked to anti-inflammatory and repair effects (Biomolecules, 2025). Because the fragments are smaller, low-molecular-weight PDRN is also suited to topical products and treatments where it is applied after microneedling. In addition, PDRN has a longer history in wound healing and tissue repair, and it is used in aesthetic medicine for skin regeneration and redness.

PN vs PDRN: Key Differences

Size and Structure

The main difference is chain length. In fact, the 2025 Biomolecules review explains that PN has much longer chains than PDRN. As a result, PN breaks down more slowly and forms a hydrated gel, whereas PDRN acts more quickly and more directly on cell receptors.

How They Feel and Behave

Because of its gel structure, PN injected into the skin can provide gentle support and hydration. In contrast, PDRN is thinner and spreads more easily, which makes it suitable for topical use and combination treatments.

Evidence

Both have promising but limited evidence. However, the Biomolecules review notes that direct comparisons between PN and PDRN are limited and that many products do not disclose their molecular weight, which makes results hard to compare. Similarly, a 2026 expert review of polynucleotides in Clinical, Cosmetic and Investigational Dermatology concluded that much of the evidence for PN comes from small studies and clinical experience, and that larger trials are needed (Rho et al., 2026). Notably, several authors of both reviews have links to the industry, so the evidence should be read with caution.

Which Skin Concerns Suit PN?

PN is often chosen for thin, crepey or tired-looking skin, fine lines and overall skin quality. Moreover, it is used under the eyes, where the skin is thin, and for some shallow acne scars. For example, Rejuran S is a thicker PN formula used for scars, which our guide to Rejuran S for acne scars explains. Likewise, PN under the eyes may help crepey skin, although it does not fix hollowing or pigment, as explained in our guide to dark circles under the eyes.

Which Skin Concerns Suit PDRN?

PDRN is often used for skin that needs calming and repair, for example after laser or microneedling. Because low-molecular-weight PDRN can be applied to the skin, it is commonly combined with microneedling to improve texture and support recovery. In addition, PDRN is sometimes used for redness and uneven tone, although evidence for these uses is still developing.

PN vs PDRN vs Other Skin Boosters

Salmon DNA boosters are just one type of skin booster. For instance, hyaluronic acid boosters focus mainly on hydration, while collagen stimulators work more gradually on firmness. To compare PN with other popular options, read Profhilo vs Rejuran or PLINEST vs Rejuran. Separately, if you are wondering how boosters differ from fillers, our guide to skin boosters vs dermal fillers explains the difference. For an overview of all options, see our skin booster treatments page.

Are PN and PDRN Safe?

Both are generally well tolerated when injected by a trained doctor. Common side effects include small bumps, redness, mild swelling and occasional bruising, which usually settle within a few days. The 2026 expert review reported that granulomas and nodules had not been described in the published PN literature to date. Even so, long-term safety data are still limited. For a detailed guide to what is normal after treatment, read Rejuran side effects and aftercare.

Who Should Avoid Salmon DNA Treatments?

Because both PN and PDRN come from fish DNA, people with a fish or salmon allergy should avoid them. Likewise, they are not given during pregnancy or breastfeeding, or where there is an active skin infection in the treatment area. People with active eczema or rosacea flares, a history of cold sores or those taking blood thinners should discuss this with their doctor first.

How to Check You Are Getting a Genuine Product

Many salmon DNA products are sold online, and some are not genuine or are not meant for injection. In Malaysia, injectable skin boosters are regulated as medical devices, so you can check registration with the Medical Device Authority (MDA). Also, ask to see the sealed box, batch number and expiry date before treatment. Finally, home-use ampoules are skincare products, not injectables, as explained in our guide to the Rejuran ampoule.

Which Is Right for You?

The right choice depends on your skin concern, skin type and goals. In general, PN may suit you if you want to improve thin, tired skin, fine lines or skin quality over a course of sessions. On the other hand, PDRN may suit you if you want a calming, repair-focused treatment, often combined with microneedling or laser. In practice, a doctor will assess your skin and may combine treatments over time. If you are also considering newer regenerative options, our page on exosome therapy explains how exosomes differ.

Frequently Asked Questions

Is Rejuran PN or PDRN?

Rejuran is a PN-based skin booster. It uses long-chain polynucleotides purified from salmon DNA.

Is PN better than PDRN?

Neither is better for everyone. PN forms a longer-lasting gel in the skin, whereas PDRN acts faster and suits topical and combination treatments. Therefore, the right choice depends on your skin concern.

Is salmon DNA the same as a filler?

No. Salmon DNA boosters improve skin quality and do not add volume or lift like fillers.

How many sessions of PN or PDRN do I need?

PN skin boosters are usually given as a course of about three to four sessions, around four weeks apart, followed by maintenance. Your doctor will tailor the plan to your skin.

Can I use salmon DNA products at home?

Yes, but home products are skincare and work differently from injections. As a result, they support in-clinic treatment rather than replace it.

Book a Skin Booster Consultation

PN and PDRN both use purified salmon DNA, but they suit different skin goals. A doctor can help you choose the right one based on an assessment of your skin. To discuss which salmon DNA treatment suits you, book a consultation with CLEO Clinic.